【samp8小鼠快速老化SAMP8小鼠实验动物模型价格低】

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samp8小鼠快速老化早老小鼠samp8小鼠、samr1小鼠部分第三方使用单位：广东药科大学、武汉体育学院、宁夏医科大学、中国中医科学院、同济医院、中科院遗传与发育研究所、北京师范大学、国家体育总局体育科学研究所、河北医科大学，中国医科大学、山东大学、齐鲁医院、复旦大学、瑞金医院、中科院上海药物研究所、上海交通大学、第二军医大学、第四军医大学、中科院生物物理所、南方医科大学、武汉协和、中国医学科学院等均使用本单位提供动物进行研究。

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samp8小鼠快速老化早老小鼠samp8小鼠起源 1968年，美国（Bar Harber ME）JAX赠送给日本京都（Kyoto）大学几对AKR/J系小鼠。在繁殖饲养过程中，Takeda等人发现有几窝小鼠表现有程度不同的脱毛、皮肤粗糙、白内障、行为障碍及生存期缩短等现象，且具有遗传倾向。1975年，他们精心挑选了5窝表现明显衰老的AKR/J小鼠作为P系祖先，表现有正常衰老过程的小鼠作为R系祖先。选择P系、R系的主要标准是以老化度评分（在8月龄时衰老程度）、生存期限及与衰老相关疾病的病理学改变为依据。根据生存曲线（Gompertzian function）及老化度评分标准得出P系小鼠的衰老特征为快速老化。因此，P系称为快速老化小鼠（Senescence accelerated mouse/prone， SAMP），R系称为抗快速老化小鼠。至善健康医学研究院引入培育。

samp8小鼠快速老化早老小鼠samp8小鼠特征与早老小鼠samp8小鼠用途

◇samp8小鼠快速老化早老小鼠samp8小鼠在增龄过程中脑内有大量Aβ沉积，Northern杂交法检测表明，β淀粉样蛋白前体(APP)mRNA表达水平无明显变化。

◇samp8小鼠快速老化早老小鼠samp8小鼠在增龄过程中出现的学习记忆功能障碍与脑内相应神经递质改变密切相关，如大脑皮层和海马部位乙酰胆碱(Ach)、去甲肾上腺素(NE)、多巴胺(DA)降低及阿片肽、γ-氨基丁酸(GABA)升高，5-羟色胺(5-HT)表现为先升高后降低等。

◇快速老化早老小鼠samp8小鼠在2月龄时就出现免疫功能异常，对绵羊红细胞(SRBC)诱导的脾细胞抗体生成反应、Con A诱导的淋巴细胞增殖反应及IL-2产生能力均明显下降。进一步研究发现，samp8小鼠快速老化早老小鼠samp8小鼠脾脏CD+4细胞数目及功能下降，NK细胞数量正常。用免疫增强剂后，NK细胞活性明显增强，表明NK细胞活性降低可能与IL-2水平下降有关。

◇samp8小鼠快速老化早老小鼠samp8小鼠用途：研究衰老与学习记忆功能及学习记忆功能障碍发生机制和评价益智药物的良好动物模型，而且是研究神经内分泌免疫调节网络平衡的良好模型。

samp8小鼠快速老化早老小鼠Samp8小鼠饲料 大小鼠繁殖料

STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs

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